The Pro380 was a desktop workstation based on the J-11 chipset. The machine was equipped with an RD50 hard drive (later RD51 or 52 also available) and ran the P/OS (a derivative of RSX-11) or RT-11 operating systems.

The J-11 processor ran at 10MHz in the Pro380 resulting in fairly lack luster performance. It was originally intended to run at 20MHz, but DEC had production problems reaching this speed and could only reach 18MHz. Unfortunately the Pro380 was designed to share a single clock between all the CPU, video and peripherals and so the CPU speed had to be forced down to 10MHz.